Healthspan Vein Vine 360mg (90 Tablets) | for Tired & Heavy Legs | Maintains Healthy Leg-Vein Functions | Red Vine Leaf Extract | Added Vitamins B1 & C | Vegan

Product Information

Red vine leaf extracts stabilise the endothelial lining of tiny capillaries and promote their repair and reduce their permeability. This makes capillaries less leaky so less fluid passes from the circulation into the tissues to cause swelling of (oedema) of surrounding tissues.

Red vine leaf extract had a beneficial therapeutic role in patients with CVI. Further high-quality trials are required to be carried out to provide strong evidence. To assess the efficacy and safety of once-daily doses of 360 and 720 mg RVLE (pharmaceutical extract code AS 195; Antistax Venenkapseln) compared to placebo in patients with stage I and incipient stage II chronic venous insufficiency (CVI). From the 56 studies, 5 trials were selected according to our inclusion criteria. Red vine leaf extract significantly improved numbers of outcomes (lower leg volume, calf and ankle circumference, tired, heavy legs, tingling sensation, pain, the sensation of tension in the legs, cutaneous microcirculation, and transcutaneous oxygen pressure) in only some trials. The tolerability for red vine leaf extract was reported good or satisfactory. One of the first studies to assess the effectiveness of red vine leaf extracts (Antistax) asked 71 people with leg swelling (due to chronic venous insufficiency) to take 360mg red vine leaf extracts, or placebo during two separate periods of 6 weeks. This meant that each person tried both treatments and acted as their own controls. A systematic literature search was performed to identify trials that reported the impact of red vine leaf extract on CVI. The primary outcomes investigated were Leg (limb) volume, calf circumference, ankle circumference, tired and heavy legs, a sensation of tension, tingling sensation, and pain.After 3 months of treatment, those who also received the red vine leaf extracts showed greater improvements in blood clotting factors and in the dissolution of the fibrin clot, with a more pronounced opening up (recanalization) of veins in the affected area. Chronic venous insufficiency (CVI) is common in adults. Some complications include skin changes, edema, heavy legs, muscle cramps, pain, and varicose veins. In traditional medicine, red vine leaf extract (AS 195) has been used to cure the symptoms of CVI. This systematic review was aimed to assess the effects of AS 195 in patients with CVI. A cooling leg gel containing red vine leaf extracts that is designed to soothe and refresh tired, heavy legs, is also available.

Red grapes are well-known for their beneficial antioxidants, and red vine leaf extracts are derived from the leaves of the same grapevine, Vitis vinifera. Red vine leaves are harvested when they achieve a rich red colour and have the highest content of antioxidant polyphenols. Their extracts are used medicinally for their circulatory effects, especially within leg veins. They reduce inflammation, stabilise the endothelial lining of capillaries and veins, and promote their repair to reduce swelling of the ankles. Red vine leaf benefits Coleridge Smith, P. D. (2001). Update on chronic-venous-insufficiency-induced inflammatory processes. Angiology, 52(1_suppl), S35-S42. Beebe-Dimmer, J. L., Pfeifer, J. R., Engle, J. S., & Schottenfeld, D. (2005). The epidemiology of chronic venous insufficiency and varicose veins. Annals of Epidemiology, 15(3), 175-184. The researchers concluded that adding angioprotectors ( red vine leaf extract) to standard medical treatment helps to correct endothelial dysfunction (the ability of veins to recover and dilate) and may improve the immediate results for patients with acute venous thrombosis. Red vine leaf dose Other studies found similar reductions in calf swelling, sensations of heaviness and pain from taking red vine leaf extracts. Red vine leaf and venous thrombosisRed vine leaf extract (RVLE) is a herbal medicine containing several flavonoids, with quercetin-3-O-beta-glucuronide and isoquercitrin (quercetin-3-O-beta-glycoside) as the main components. Researchers next assessed the best dose in a 12-week study involving 257 men and women with mild to moderate chronic venous insufficiency. One group took 360mg red vine leaf extracts per day, one took 720mg daily, while another took placebo. This was followed by another study, involving 248 patients with more severe chronic venous insufficiency, classed as moderate-to-severe. Half took 720 mg red vine leaf extract per day for 12 weeks, while half took inactive placebo. The red vine leaf extract significantly reduced lower limb volume by 20 ml more than placebo (27ml versus 7ml) with an associated decrease in leg pain. Russian physicians recently added red vine leaf extracts to the immediate medical treatment of patients presenting with acute deep vein thrombosis (blood clots in a large vein in the lower leg). Symptoms of chronic venous insufficiency include feelings of heaviness, aching legs, swelling of the ankles or calves, sensations of tension in the legs and pain. The overlying skin may become dry and discoloured and acquires a characteristic mottled pigmentation.